| Date | Team | Opponent | Time (ET) | TV |
| Thursday, March 29 | Detroit Tigers | vs. Pirates | 1:10 PM | FSDT |
| Saturday, March 31 | Detroit Tigers | vs. Pirates | 1:10 PM | FSDT |
| Sunday, April 1 | Detroit Tigers | vs. Pirates | 1:10 PM | FSDT |
| Monday, April 2 | Detroit Tigers | vs. Royals | 1:10 PM | FSDT |
| Tuesday, April 3 | Detroit Tigers | vs. Royals | 1:10 PM | FSDT |
| Wednesday, April 4 | Detroit Tigers | vs. Royals | 1:10 PM | FSDT |
| Thursday, April 5 | Detroit Tigers | at White Sox | 4:10 PM | FSDT |
| Saturday, April 7 | Detroit Tigers | at White Sox | 2:10 PM | FSDT |
| Sunday, April 8 | Detroit Tigers | at White Sox | 2:10 PM | FSDT |
| Monday, April 9 | Detroit Tigers | at Indians | 6:10 PM | FSDT |
| Tuesday, April 10 | Detroit Tigers | at Indians | 6:10 PM | FSDT |
| Wednesday, April 11 | Detroit Tigers | at Indians | 6:10 PM | FSDT |
| Thursday, April 12 | Detroit Tigers | at Indians | 6:10 PM | FSDT |
| Friday, April 13 | Detroit Tigers | vs. Yankees | 7:10 PM | FSDT |
| Saturday, April 14 | Detroit Tigers | vs. Yankees | 1:10 PM | FSDT |
| Sunday, April 15 | Detroit Tigers | vs. Yankees | 1:10 PM | FSDT |
| Tuesday, April 17 | Detroit Tigers | vs. Orioles | 6:40 PM | FSDT |
| Wednesday, April 18 | Detroit Tigers | vs. Orioles | 6:40 PM | FSDT |
| Thursday, April 19 | Detroit Tigers | vs. Orioles | 1:10 PM | FSDT |
| Friday, April 20 | Detroit Tigers | vs. Royals | 7:10 PM | FSDT |
| Saturday, April 21 | Detroit Tigers | vs. Royals | 1:10 PM | FSDT |
| Sunday, April 22 | Detroit Tigers | vs. Royals | 1:10 PM | FSDT |
| Tuesday, April 24 | Detroit Tigers | at Pirates | 7:05 PM | FSDT |
| Wednesday, April 25 | Detroit Tigers | at Pirates | 7:05 PM | FSDT |
| Thursday, April 26 | Detroit Tigers | at Pirates | 12:35 PM | FSDT |
| Friday, April 27 | Detroit Tigers | at Orioles | 7:05 PM | FSDT |
| Saturday, April 28 | Detroit Tigers | at Orioles | 7:05 PM | FSDT |
| Sunday, April 29 | Detroit Tigers | at Orioles | 1:05 PM | FSDT |
| Monday, April 30 | Detroit Tigers | vs. Rays | 7:10 PM | FSDT |
